Sentence examples for modulate aggregation of from inspiring English sources

The lead compounds -8a and -14 were able to modulate aggregation of α-synuclein protein efficiently.

The use of small aptameric nucleic acids and other polyanions has been proposed to modulate aggregation of the prion protein [ 47, 62, 84].

Among the approaches aimed at improving cell survival in the presence of mutant huntingtin are correction of transcriptional regulation using histone deacetylase inhibitors, modulating aggregation of huntingtin, improving metabolism and mitochondrial function and restoring dysfunction of synapses.

We showed that the Josephin domain plays a pivotal role in modulating aggregation of full-length nonexpanded ataxin-3, by dictating its stability and self-association properties (29).

Overall, these findings support the hypothesis that changes in negative charge may play an important role in modulating aggregation of SOD1.

Although this interaction was mapped to the C-terminal region and not to Josephin, it also modulates aggregation of ataxin-3 and reduces its toxicity in an in vivo model (46).

Third, phosphorylation of TDP-43 may modulate aggregation and toxicity of the protein [ 26, 126].

Hsp70 proteins and their co-chaperones have been shown to modulate aggregation in models of neurodegenerative diseases.

A number of in vitro studies showed that dopamine can modulate the aggregation of α-synuclein by inhibiting the formation of or by disaggregating amyloid fibrils [5], [6], [7].

By combining experimental and theoretical studies of a model peptide we have revealed new features of how phosphorylation can modulate the aggregation of a peptide sequence.

Binding to lipid vesicles can modulate the aggregation of α-syn and the effect of lipids on fibril formation is dependent on α-syn conformation.