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smt3 protein may modulate activity of transcription factors in the follicle cells downstream of EGFR activation.
PhoP and CpxR are dual transcriptional regulators that are activated in response to environmental stimuli and then act to modulate activity of other genes [ 23, 24].
Although inhibition mediated by fast-spiking interneurons is described57, we found here that layer 2/3 pyramidal neurons in the human cortex modulate activity of surrounding pyramidal neurons through delayed lateral inhibition mediated by putative MCs.
Recently, we reported that PC1 expression levels modulate activity of Gα12-stimulated apoptosis (Yu et al., J. Biol. Chem. 2010 285 14):10243-51).
These variations in the CYP24A1 response not only confirm the high sensitivity of this particular cell line to xenobiotic exposure but also provide further evidence to support the role of VDR as a potential target for xenobiotics that is able to bind structurally diverse endogenous and exogenous compounds and modulate activity of other important genes accordingly.
In detail however, drugs modulate activity of dysfunctional proteins or their functional counterparts aiming to reduce the pathogenic effects.
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Genistein has been shown to modulate activities of PTKs [25], [26], [27].
In the kidney, HNF-1β, a transcriptional factor, has been shown to modulate activities of several target genes in tubular epithelia, namely Umod, Pkhd1, Pkd2 and Tg737/Polaris.
Suntsova, N. et al. The median preoptic nucleus reciprocally modulates activity of arousal-related and sleep-related neurons in the perifornical lateral hypothalamus.
In addition, Spt5 interacts and modulates activity of factors implicated in mRNA maturation and surveillance [23] [25].
These observations provide a plausible mechanism for the chromatin modulating activity of core X and Y'.
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