Genistein has been shown to modulate activities of PTKs [25], [26], [27].
In the kidney, HNF-1β, a transcriptional factor, has been shown to modulate activities of several target genes in tubular epithelia, namely Umod, Pkhd1, Pkd2 and Tg737/Polaris.
Through direct interaction, ECM proteins could modulate activities of many growth factors, cytokines, chemokines, and extracellular proteins or elicit signal transduction cascades, thus regulating diverse cellular functions.
Reversible reactions of NO with functional groups such as haem and thiols have been shown to modulate activities of proteins (Graziano et al., 2002; Graziano and Lamattina, 2005).
Flavonoids have been found to modulate activities of at least four CYP450 isoforms of importance for xenobiotic metabolism: CYP1A1, 1A2, 1B1, and 3A4 [ 17].
Alternatively, PL can also modulate activities of other proteins involved in the invasive behaviour of breast cancer cells (e.g. matrix metalloproteinases, β1 and β4 integrins, epidermal growth factor receptors and others (Carraway and Sweeney, 2006; Bissell, 2007)).
smt3 protein may modulate activity of transcription factors in the follicle cells downstream of EGFR activation.
In detail however, drugs modulate activity of dysfunctional proteins or their functional counterparts aiming to reduce the pathogenic effects.
However, WT- and PTX3−/−-MSCs did not seem to modulate activity of MMP13 in 1 week (Additional file 1: Figure S2) to impact remodeling and fibrosis.
Recently, we reported that PC1 expression levels modulate activity of Gα12-stimulated apoptosis (Yu et al., J. Biol. Chem. 2010 285 14):10243-51).
LPS can modulate activity of cPLA2 by phosphorylation [ 20].
