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CB1 and CB2 receptors modulate a wide variety of physiological systems including analgesia, memory, mood, reward, appetite and immunity.
mTOR is a highly conserved kinase and a central component in signaling cascades that modulate a wide range of metabolic processes.
Since then, CRF has been shown to modulate a wide variety of brain regions outside of the traditional HPA axis, including the NAc.
Those acidic sugars impart net negative charge and are in a position to modulate a wide variety of events in cell-cell, cell-matrix and cell-molecule interactions [1].
It has been documented that members of the FOXO subfamily are involved in various signaling pathways and modulate a wide range of biochemical processes, such as cell cycle progression, differentiation, DNA damage repair, and programmed cell death [13].
The RNA regulators, named small RNAs (sRNAs) in prokaryotic organisms, constitute a heterogeneous group of molecules that act by various mechanisms to modulate a wide range of physiological responses.
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Thrombospondin-1 (TSP-1) is a homotrimeric glycoprotein which modulates a wide range of biological functions.
Butyrate modulates a wide range of processes, but its mechanism of action is mostly unknown.
Ca2+ modulates a wide range of cellular activities, including gene transcription, metabolism and programmed cell death [3].
Because S1P modulates a wide range of physiological processes, its concentration must be tightly regulated within both intracellular and extracellular environments.
In addition to octanol sensitivity [13], [18], DA modulates a wide range of C. elegans behaviors, including food sensing, area restricted search, locomotion, egg-laying, defecation, state-dependent olfactory adaptation and habituation to non-localized mechanical stimulation (tap) [31], [32].
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