Sentence examples for modulate a target from inspiring English sources

Next, each of the 57 sequences was assessed for druggability that is defined as the likelihood of being able to modulate a target's activity with a small-molecule drug [27], [28].

The variable levels were optimized in order to modulate a target property without appreciably affecting other dependent properties.

Importantly the E2/E3 ligase set likely functions to degrade or modulate a target protein(s) whose non-ubiquitinated function shortens lifespan in stressful conditions such as low nutrient availability and high temperature.

Computer-aided drug design (CADD) and, in particular, ligand-based drug design provide a myriad of tools to identify rapidly new chemical entities for modulating a target based on previous knowledge of active compounds without relying on a ligand complex.

Hence, the discovery of efficacious MMP inhibitors without strong zinc-binding functional moieties is a very active field of research toward the generation of clinical treatments for those serious conditions.[ 16] Peptide bonds of the protein backbone represent the ubiquitous binding motif for small molecules to modulate a biological target.

However, it seems unlikely that modulating a single target will provide an effective therapy; in addition, given the ubiquity of these targets and their functions in a very broad range of cell types it may be anticipated that adverse effects will limit their utility.

It seems clear that therapies modulating a single target yield nothing but minor alteration of a diseases complex machinery.

Thus, we conclude that RIF may activate DAF-16 differently and modulate a separate subset of target genes compared to the ones regulated by the IIS pathway.

miRNAs can modulate a wide variety of targets, which endowed the supposition that a single miRNA might regulate cancer progression in multiple steps by targeting numerous genes.

Our cumulative evidence demonstrates that REST and CoREST modulate an array of target genes, including those with roles in CHOLN morphology and maintenance as well as other genes that actively suppress the elaboration of alternate neuronal subtypes.

Future therapies may utilize small RNAs or various chemically modified oligonucleotides to epigenetically modulate a gene transcription or to target endogenous ncRNAs actively involved in regulating particular genes expression.