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While DNA polymerase β preferentially incorporated dCTP over dATP, DNA polymerase λ did not modulate a preference for either dCTP or dATP when opposite 8-oxodG in single-nucleotide gapped DNA, as incorporation proceeded with essentially equal efficiency and probability.
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Biologicals are large molecule drugs that modulate a variety of cellular and immunological functions.
Given that kinase and substrate have complementary sequences in a 3D space, stabilization of the activation loop in a certain position may modulate substrate preference by shifting the interactions of the complementary sequences.
Passionflower controls anxiety by modulating a neurotransmitter called GABA.
Deletions in the HLE modulate the substrate preference of human RNase L (Korennykh et al. 2009; Han et al. 2014).
More mildly, marketing companies could use these techniques to modulate customers' preferences and attitudes towards their products.
Targeted interventions to modulate facility preferences may be particularly productive toward this end.
This aspect is of significance to modulate the binding preferences of the mimics for ribosomal A- versus P-site.
In particular, these derivatives are promising to modulate the binding preferences of the mimics for ribosomal A- versus P-site in crystallographic studies.
The new structures of A. niger PhyA are discussed in the context of protein engineering studies aimed at modulating pH preference and stability.
Together, these findings suggest that endogenous nociceptin differentially modulates diet preference depending on macronutrient content and homeostatic state, independently of the motivating, rewarding or orosensory properties of food, but may involve metabolic or postingestive processes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com