BDNF also modulates GABAergic transmission [5] [37], which underlies oscillatory activities, but, to our knowledge, there has been no direct evidence so far that BDNF influences oscillations through GABAergic neurons.
It may be that it modulates GABAergic transmission in the central amygdala, a brain region implicated in the regulation of emotionality and alcohol intake [ 33, 34].
It was recently revealed that ghrelin modulates GABAergic transmission in the rat amygdala by increasing inhibitory postsynaptic potential amplitudes in both naive and alcohol-dependent rats via pre- and post-synaptic mechanisms.
NASs bind to a distinct site on the GABAA receptor and influence the frequency and duration of the chloride channel openings, thus modulating GABAergic transmission and GABA mediated behaviors (Paul and Purdy 1992; Lambert et al. 1995; Majewska 1992; Concas et al. 1999).
Compounds that potently block muscarinic receptors, interact with the NMDA ion channel and in addition are able to modulate σ1 sites and/or GABAergic transmission seem to represent the emerging backbone for novel antidotes against OP poisoning.
Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.
Recent experimental evidence provides considerable support to the notion that locally produced neurosteroids can enhance GABAergic transmission, and hence modulate neuronal excitability.
These effects could be modulated, among others, via neuromodulation of GABAergic transmission and less directly by modifying neurotrophin expression, a notion supported by the fact that inducible neurotrophins are downregulated by GABA activity [ 12].
GABAergic transmission in the amygdala modulates the expression of anxiety.
DOI: http://dx.doi.org/10.7554/eLife.07192.005 We also tested the robustness of UC and UH for modulating firing levels during blockade of AMPAergic, NMDAergic, or GABAergic transmission using CNQX, AP5, or bicuculline, respectively ('Materials and methods').
