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Two novel imaging agents trastuzumab-Cy5.5-CHX-A″ 1 and cetuximab-Cy7-CHX-A″ 2, bearing both a chelating moiety (CHX-A″) for sequestering metallic radionuclides (86Y or 111In) and the near infrared dye Cy5.5/Cy7, were prepared by a novel modular synthetic strategy as examples of dual-labeled, antibody-based imaging probe library.
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Most recently, Koffas and coworkers applied a modular synthetic biology strategy to optimize the transcription of fatty acid metabolic pathway, which consists of the modules of upstream acetyl-CoA formation, intermediary acetyl-CoA activation and fatty acid synthase (Xu et al., 2013).
These compounds were assembled with a modular build/couple/pair synthetic strategy using different olefin-containing carboxylic acid and amino alcohol building blocks.
Modular, multicomponent synthetic strategies have proven valuable for the discovery of novel polymeric materials.
Short, modular synthetic pathways, for example, using the build/couple/pair (B/C/P) strategy, facilitate downstream efforts using medicinal chemistry.
A modular synthetic approach toward exhaustively stereodiversified ligand libraries.
The flexible synthetic strategy allows molecular diversity.
The present feature article highlights our recent efforts to develop modular synthetic platforms in macromolecular synthesis.
A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and isoxazolidines is described.
The synthesis of ORR and OER hybrid electrocatalysts followed the general synthetic strategy developed in our lab8,9,10,11,12,13.
The synthetic strategy used herein yields uniformly shaped monodisperse particles.
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