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The usefulness of our method is illustrated on the RNA polymerases for which the modular substructure can be successfully reconstructed.
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Unfortunately it is rarely evident when population substructure can be ignored.
In Figure 5, the effect of removing some layers from the FN substructure can be observed.
The database is designed so that a group of substructures can share one FGROUP, and a single substructure can belong to two or more FGROUPs.
For substructure identification, our server provides a simple method of rapidly sieving aligned structures such that conserved substructure can be identified.
Substantial population substructure can be observed by the nonrandom grouping of population groups that extends through PC7.
This substructure can hamper the search of susceptibility genes for common complex disorders leading to spurious correlations.
As a consequence, these networks reflect the modular substructure of the corresponding complexes.
The modular substructure and the physical interactions within the protein complexes have been mostly ignored.
Population substructure can induce spurious associations in genetic association studies.
The actual and simulation experimental results indicate that the presented comb-like damped substructures can be effectively functioned as a modular damper for a circular hinge and the damped flexure hinge can be designed independently of its damping and stiffness when low elastic viscoelastic material adopted.
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