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All sex steroid receptors are built with similar modular structure, including a DNA-binding domain, a hinge region with a nuclear location signal, and a ligand-binding domain.
As explained in detail in Fig. 1, all Gab proteins share a similar modular structure, including a PH domain at their N-terminus, proline-rich regions in the central part and multiple phosphorylated tyrosine residues.
Human PDI has a modular structure including four TRX-like domains (a, b, b' and a' ), a linker (x) and a C-terminal extension domain (c ) [for reviews see [ 12, 13]].
Most of these effectors have a modular structure including different motifs that mimic the function of these large actin-binding proteins and regulatory factors of actin dynamics such as Rho GTPases, Nck, N-WASP, among others.
The 71,777 bp nucleotide sequence of pAW63 reveals a modular structure, including a 42 kb tra region encoding homologs of the Type IV secretion systems components VirB11, VirB4 and VirD4, as well as homologs of Gram-positive conjugation genes from Enterococcus, Lactococcus, Listeria, Streptococcus and Staphylococcus species.
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NRs share a modular structure, which includes highly conserved DNA- and ligand-binding domains (DBDs, LBDs) spaced by a variable hinge region [1], [2].
This family of nonreceptor tyrosine kinases has a modular structure, which includes one SH2 and one SH3 domain.
Multiple xylanases are produced in the fungal cellulase system and a large number of GH10 xylanases found in basidiomycota and ascomycota have a modular structure that include a family 1 carbohydrate-binding module (CBM1) at N- and C-termini [ 18, 19].
We apply the LEMONS algorithm to investigate the performance of 17 chemical fingerprints with respect to modular natural product structures, including linear and cyclic nonribosomal peptides, polyketides, and hybrids, with a diverse range of tailoring reactions and starter units.
But Intrawest was able to open in 60 days by erecting six temporary modular structures that include a 600-seat restaurant, bar and lounge.
The simple modular structure of Rev, including its pliable protein protein interface and diverse RNA-binding domain, highlights how a virus with limited coding capacity can build a large, asymmetric RNP using a small, homo-oligomeric protein to achieve remarkable structural and functional complexity.
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