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The helicase core domains of Mss116 have modular roles in substrate loading (Mallam et al., 2012 ).
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SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise several dozen modular enzymes that have diverse roles in biological regulation.
Carbohydrate-binding modules, in particular, are known to partake in complex modular architectures that play crucial roles in numerous biochemical and molecular processes.
Basic region leucine zippers (bZIPs) are modular transcription factors that play key roles in eukaryotic gene regulation.
Connections and joints play key roles in design for deconstruction and modular construction, which are two of the innovations making building construction sustainable.
Within such modular networks, osteopontin (OPN) and E-cadherin play important roles in growth responses to vitamin D [65,66].
Several groups of mono/bi-modular NRPS metabolites are predicted to play more pivotal roles in cellular metabolism than products of multimodular NRPSs.
In addition, phylogenomic relationships among subfamilies, taxonomic distributions, structural conservation of domain architecture, and known data on function suggest that several of the mono/bi-modular groups are older in origin and play more central roles in cellular metabolism.
Signal features are biologically functional regions including core-promoter elements [ 11, 12], some short modular transcription factor binding sites (TFBSs), and CpG-islands [ 13], which play important roles in assembly of transcriptional machinery.
Connections between the modular units play a central role in providing integrity in modular buildings.
All of the remaining mono/bi-modular subfamilies show remarkably conserved domain architectures (Fig. 5, 10B), supporting available functional data which suggests these groups may have more central conserved roles in metabolism.
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