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The small size, minimal targeting constraints, and modular regulation of Cas13d effectors further expands the CRISPR toolkit for RNA manipulation and detection.
Until now, the possibility that FGF8 could add to the modular regulation of its activity in neurons by autoregulating its own receptor has not been adequately explored.
These examples are just two among many in teleosts that suggest modular regulation of the developmental modes we have described, as could be critically examined by looking more closely at the appropriate stages of the developing sucker and pike.
The results of the 'cis' and 'trans' analyses provide information concerning the modular regulation of lncRNAs.
The results of the 'cis' and 'trans' analyses provide information concerning the modular regulation of lncRNAs, representing the third highlight of the present study.
Our findings are similar to those recently published on burrowing patterns in deer mice and schooling behavior in sticklebacks (Greenwood et al. 2013; Weber et al. 2013), providing initial evidence that modular regulation of variation in behavior may be common.
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28 out of 32 transcription factors in module P were interface genes that were interacting with module D, indicating the importance of inter-modular regulation of cellular growth and cellular trafficking.
Regarding CH hearts, due to the absence of modification in RPP or [PCr] following oxygen decrease (figure 1D), modular regulation analysis reflected this absence of effect as illustrated in figure 2B.
If the modular kinetics are remeasured after some functional change, one can quantify how that change propagates through the system (modular regulation analysis) [ 34].
Using such a framework, complex post-translational modifications of the CTD are viewed as a means for the dynamic "programming" of Rpb1p by CTD effectors, and thus, for the modular transcriptional regulation of discrete regulatory networks in eukaryotes.
We show that the expression of multiple cellular miRNAs was altered and provide evidence that miRNAs are involved in a combinatorial and modular fashion in the regulation of host responses during HCV infection.
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