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Mechanical unfolding and refolding may regulate the molecular elasticity of modular proteins with mechanical functions.
NRPSs, PKSs, and hybrid NRPS/PKSs are modular proteins with similar assembly-line organizations.
These results demonstrate the high potential of recombinant modular proteins with merging biological functions to fulfill several requirements needed to obtain cost-effective non-viral vectors for gene-based therapies.
However, lamins are modular proteins with two distinct domains; the filament and IF-tail, and domain-limited sequence similarities could have gone undetected.
Sex steroid receptors are modular proteins with distinct functional domains).
Ets TFs are modular proteins with the Ets domain generally present at either terminus [ 2].
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This second principle leads to designs whereby co-expression of modular protein with unmodified VLP-forming protein can titrate down the amount of antigen on the surface of the VLP, to the point where assembly can proceed.
Biophysical analyses show that hArc is a modular protein with defined secondary structure and loose tertiary structure.
Human U2A′ is a modular protein with a 180-amino acid N-terminal leucine-rich repeat (LRR) domain and a C-terminus predicted to be mostly disordered (IUPRED).
Despite the high amount of observed and predicted α-helical secondary structure in hArc, hArc appears to be a flexible and modular protein, with loose 3D structure both within each domain and between domains.
They are frequently associated with modular proteins, and are involved in complex carbohydrate degradation [ 38] and the binding of proteins with extracellular matrix components, such as the laminin binding protein.
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