Third, there were no approaches which generated large, comprehensive collections of high-quality modules resulting from exhaustive screens of the modular organization of organisms.
Apart from convenience in such annotation-specific module discovery tasks, exhaustive collections may also provide a global picture of the modular organization of an organism.
When we compare the nervous system of C. elegans with the brains of higher organisms, we observe the modular organization of the latter to be more prominent [70].
Here we introduce the quantitative measure (Modularity density D) for exploring modular organization of networks to the field of biomolecular networks.
The above results indicate that the relation between the functional circuits, which are essential for the survival of the organism, are reflected in the modular organization of the nematode nervous system.
We suggest that the modular organization of signaling networks are differently organized in the two cell types (Fig. 1).
A survey of 77 completely sequenced eukaryotic genomes implies a potential hierarchical and modular organization of biological functions in most living organisms.
Modularity Q have been extensively employed for dissecting and evaluating the modular organization of biomolecular networks [ 3, 17- 19] as well as clustering the graphic representation of gene expression profile data [ 31].
We review theories to explain modular organization of biology, with a focus on explaining how biology may spontaneously organize to a structured form.
While at the cellular level the modular organization of molecular interactions has been analyzed in detail, the phenotypic modularity (or variational modularity) of cell shape remains unexplored.
MFE-2 has a modular organization of three domains.
