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As a first step towards the structural characterization of Henipavirus N and P proteins, we herein describe the results of a thorough computational analysis that shows that Henipaviruses N and P proteins possess a modular organization consisting of large (up to 400 residues) unstructured regions alternating with structured regions.
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These homologous proteins are related to each other both in terms of sequence and predicted structure, possessing a conserved modular organization [2], [3], [19], [20] consisting of (i) an N-terminal signal sequence, (ii) a highly conserved N-terminal β-domain and (iii) a C-terminal surface localized "passenger" domain.
Our results are also consistent with the modular organization reported in several recent human brain networks studies.
A thorough understanding of the modular organization is a prerequisite for lymphoid organ tissue-engineering.
This is consistent with a more modular organization of the regulatory machinery, which is also evident from the network representation.
We suggest that the modular organization of signaling networks are differently organized in the two cell types (Fig. 1).
Much of the literature on modularity assumes that firms with modular products adopt modular organization.
MFE-2 has a modular organization of three domains.
(2) Such systems, when complex, need to have massively modular organization.
DNA nucleotides can be modified independently of each other, a property referred to as modular organization; it has been argued that coded information requires modular replication (Szathmáry 2000).
The nerve fiber network of the mammalian cerebral cortex possesses a modular organization extending across several levels of organization.
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