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The present networks uncover hitherto unrecognized modular interactions between chaperone families and their interacting proteins.
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Additional file 2: Consensus modular interactions.
Reversible complexes involve composite interfaces from modular preformed and unstructured regions that provide strong, specific contacts from the combination of relatively weak, modular interactions.
Other graph-based formalisms include modular interaction networks (Yartseva et al. 2007) and logical interaction hypergraphs (Klamt et al. 2006).
A third recognized role of the WDR is to act as a modular interaction domain of larger proteins.
Our results additionally showed inter-modular interactions via "network hubs".
On the other hand, Gavin et. al., in [4] found that an 83% of proteins of Saccharomyces cerevisiae form complexes containing anywhere from two to eighty three proteins; over 90% of these aggregates had at least one component that was not found in other sets and the whole enzymatic structure is conformed by a modular network of biochemical interactions between protein complexes.
PINs have a modular structure, in which interactions between proteins are much denser within a module than between modules [ 32].
Interactions between modular domains and short linear motifs (3 10 amino acids peptide stretches) are crucial for cell signaling.
Recently, Grunberg et al. (2010) proposed a framework for the design of synthetic protein networks using interactions between modular proteins.
The complex composition of the intra-organelle matrix arises and is maintained by weak, multivalent interactions between modular proteins and RNA.
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