Likewise, intra-modular hubs of the highest connectivity for each stage of comparison were also listed in Table 3. Top 10 enriched canonical pathways resulted from the IPA analysis using the verified gene lists were quite different from those using the full gene lists.
We did network topological analyses and identified significant inter-modular hubs with the highest informational scores.
One of the most striking observations made here was that the essential genes and phenodiv genes were intra-modular and inter-modular hubs, with the former being highly co-expressed with its interactors contrary to the latter.
Essential and phenodiv genes were found to be intra-modular and inter-modular hubs with the former being highly co-expressed with their interactors contrary to the latter.
We found that essential and phenodiv genes were intra-modular and inter-modular hubs, with the former being highly co-expressed with their interactors contrary to the phenodiv genes.
In this paper, we study the modular hub location problem, which explicitly models the flow-dependent transportation costs using modular arc costs.
In the integrin signaling networks of the HNSCC transcriptome, we identified several repressed inter-modular hubs: ACTN2, CAPN3 and TTN in Pre and TvN; and ILK, RHO-G and VCL in Meta.
Unlike seed-based functional connectivity and sICA, which focus on a specific functional system s), graph theory usually explores the topological properties, such as small-world, modular structure and highly connected hubs, of the entire brain.
An inter-modular hub-designated as a cut node in the graph - would cause the original component breaking down into different blocks upon removal of itself, leading to the blockade of signaling crosstalk.
If an inter-modular hub i was disrupted, i.e. removed in the interacting network, we estimated the potential for pathophysiological perturbation by the informational score (fi), computed by the number of blocked out paths divided by the number of breaking down components.
