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The approach described, that of assessing microbial genome inventory and testing putative modular gene expression by mRNA quantification, is likely to remain an important tool in understanding individual microbial contributions within microbial community activities that maintain the Earth's nitrogen balance.
There were no significant correlations between modular gene expression levels and CD4+ T effector memory, CD8+ naïve, and CD8+ terminally differentiated T cells.
There were no significant correlations between the total number of CD19+ B cells, nor B cell subpopulations such as naïve B cells, memory B cells, transitional B cells, pre-germinal center B cells, and plasma cells B cell and modular gene expression patterns (Table S2).
Therefore, modular gene expression may be relevant for cortical patterning in gyrencephalic species.
Importantly, we found no indication of modular gene expression at this early stage.
Taken together, our observations strongly suggested that modular gene expression may be a relevant feature underlying the formation of gyri and sulci, although the specific combination of genes involved is likely to vary between each gyrus and sulcus.
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The deduced promoter positions are consistent with a modular arrangement and imply that there is modular control of gene expression.
In many organisms, in-depth transcriptome analysis has revealed the modular architecture of gene expression [ 22].
Finally, we analyzed the modular features of gene expression in CitrusNet.
The research on modular relations in gene expression will be valuable for revealing the mechanism of gene regulation.
In such proteins the multiple DNA-binding domains can result in DNA cross-linking and chromatin compaction, and can enable both specific and modular regulation of gene expression by single proteins.
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