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"It's good modular engineering," Mr. Straubel said.
Facilities are designed with generic and adaptable features such as modular engineering and systems furniture to maximize interior flexibility and sale or subleasing potential.
In this work, we improve GlcNAc production through modular engineering of B. subtilis.
Here, a stepwise modular engineering approach was introduced to systematically identify and eliminate metabolic pathway bottlenecks.
Modular engineering enables the construction of chimeric polypeptides in which selected domains, potentially from different origins, provide the required activities.
Furthermore, we optimized the pathway by a modular engineering approach and deleting genes involved in the regulatory and competing pathways.
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This work significantly enhanced GlcNAc production through modular pathway engineering of B. subtilis, and the engineering strategies used herein may be useful for the construction of versatile B. subtilis cell factories for the production of other industrially important chemicals.
By increasing the accessibility of modular tissue engineering, we hope to enable its use in applications outside of tissue engineering, and to provide a simple method for biological investigations of the behavior of cells in 3D at high density.
Here, we describe experimental protocols and considerations for modular PKS engineering and two case studies to produce commodity chemicals by engineered PKSs.
Modular tissue engineering was initially introduced as a method of building intrinsically vascularized tissue engineered constructs by mixing together smaller building blocks ("modules"), with each module designed to include both vascular cells as well as functional cells.
Modular tissue engineering is featured as an example.
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