Modular Engineered Tissue Surfaces (METS) uses the well-known, but largely under-utilized self-adhesion properties of de novo tissue to create large scaffolds with nutrient channels.
We describe a genetically encoded anti-inflammatory mammalian cell device based on a modular engineered genetic circuit comprising a sensor, an amplifier, a "thresholder" to restrict activation of a positive-feedback loop, a combination of advanced clinically used biopharmaceutical proteins, and orthogonal regulatory elements that linked modules into the functional device.
and reassigned to Fort Hood, Texas as the United States Army's first modular engineer brigade headquarters.
Ramirez, C. L. et al. Unexpected failure rates for modular assembly of engineered zinc fingers.
Here we report a modular development of engineered bacteria for successful BD bio-production.
Kang S, Kim CU, Gu X, Owens M, van Rijn S, Boonyaleepun V, Mao Y, Springer TA, Jin MM, "Complex structure of engineered modular domains defining molecular interaction between ICAM-1 and integrin LFA-1," PLoS ONE 7 8), e44124 (2012).
Together these data suggest that a functional non-thrombogenic layer of EC was generated on the module surface and that this layer should be sufficient to maintain continuous blood flow through an engineered modular tissue.
As a proof-of-principle, we coupled these ester modules with an engineered, modular, Escherichia coli chassis in a plug-and-play fashion to create microbial cell factories for enhanced anaerobic production of a butyrate ester library.
Based on an engineered modular genetic AND logic gate, we report the construction of a set of scalable synthetic microbe-based biosensors comprising exchangeable sensory, signal processing and actuation modules.
Here, we employ both single cell type and multiple cell type populations, pre-programmed with engineered modular cell signalling and sensing circuits, as processing units to sense and integrate multiple environmental contamination associated signals.
Here, we employ both single and mixed cell type populations, pre-programmed with engineered modular cell signalling and sensing circuits, as processing units to detect and integrate multiple environmental signals.
