Sentence examples for modular domains in from inspiring English sources
van Der Houven Van Oordt, W., Newton, K., Screaton, G. R. & Caceres, J. F. Role of SR protein modular domains in alternative splicing specificity in vivo.
They frequently direct the assembly of protein complexes and mediate signal transduction in ways analogous to small modular domains in water-soluble proteins.
We discuss the phosphopeptide binding of modular domains in DNA damage responses, FHA and BRCT, the smallest modular domain WW and the tyrosine kinase binding domain, such as Cbl TKB that recognizes phosphotyrosine.
With cancer parts lists in hand, new approaches to personalized medicine can be developed by understanding the assembly of cancer machines using modular domains in proteins and their associated networks.
Kinase modular domains in CDSs were more conserved than inter-domain regions.
Thus different combinations of modular domains in a protein should be considered in generating the potential interacting domain patterns.
Further, a preliminary analysis of missense variants in MCPH1 and MDC1 suggests structural inference may help reliably annotate variants in modular domains found in multiple proteins.
The targeting moiety was derived from the modular domain present in αL integrin, which was engineered for high affinity and cross-reactivity with human and murine ICAM-1.
This connection may be mediated by the pleckstrin homology domain, a modular domain found in many signaling proteins that interact with G beta gamma.
Members of the CCN family share four conserved cysteine-rich modular domains that trigger signal transduction in cell adhesion, migration, proliferation, differentiation, and survival through direct binding to specific integrin receptors and heparan sulfate proteoglycans.
It consists of four structural domains: helicase domains 1 and 2 (HD1 and HD2), which contain all helicase signature motifs important for coupling ATP binding and hydrolysis to directional translocation along ssDNA, and two unique modular domains (ARCH and FeS) inserted in the conserved motor core.
