Exact(1)
This feature as well as the universality of GST-tagging could allow SH2-PLA to serve as a prototype for the development of powerful, convenient modular domain based proteomic tools [ 45].
Similar(7)
Most models of Unc45 portray the protein as comprised of three independent modular domains based on these homology regions (cf. Fig. S3) [4].
It has since moved to other domains based outside America.
The proposed approach supplements uncertain sensor input using Bayesian network modeling and enhances the efficiency in modeling and reasoning processes using modular design based on domain knowledge.
Based on our previous observation that T2D may result from disturbed protein-protein interactions affected through disrupting modular domain interactions, here we have designed an approach to rank the candidates in the T2D linked genomic regions as plausible disease genes.
Each subunit shares a modular domain architecture: an amino terminal domain (ATD) followed by a ligand-binding domain (LBD), a transmembrane domain and a carboxyl terminal domain.
The four mammalian Notch receptors (Notch1-4) all have a similar modular domain organization.
The proteins nhr_67 and ESR1 contain the PF00105 domain, whereas daf-21 and HSP90AA1 contain the modular domain (PF02518, PF00183).
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