Building Cellular Connectivity Where None Exists to Bridge the World.
Mammalian brains have (patchy) modular connectivity and cortices.
Further, we consider a modular connectivity design, in which the network is subdivided into many modules.
Within patients, associations between anatomical and functional modular connectomics were tested with regression analyses, as were correlations of multimodal modular connectivity and seizure frequency/duration.
55 Previous studies in TLE only using regular connectivity instead of modular connectivity have indicated the importance of DMN integrity for cognitive functioning.
DD values around 1 indicate preserved modular DMN dynamics, while deviating values indicate a shift in DMN modular connectivity toward less integrated functioning and more outward connectivity in either of the two DMN components.
Therefore, modular connectivity within this functional module was quantified by a DMN disintegration (DD) score, defined here as intramodular connectivity in the anterior part divided by intramodular connectivity in the posterior part of the DMN.
Group differences in modular connectivity were tested with regression analyses, and were corrected for multiple testing using the false discovery rate (FDR).
Additionally, a mediation model with higher seizure frequency relating to increasing anatomical modular connectivity through higher DD also yielded significant results (Fig. 6; 95% CI 0.0001 to 0.0011).
Table 2 shows the top 10 genes with increased intra-modular connectivity (some modules do not have 10 tops and hence a reduced number is displayed), where we may notice that a few genes overlap between modules (only 28 genes of 145 selected higher).
