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The TIGR4 and SP3-BS71 strains of Streptococcus pneumoniae each produce family 98 glycoside hydrolases, called Sp4GH98 and Sp3GH98, respectively, which have different modular architectures and substrate specificities.
Moraïs et al. (2012) employed a synthetic biology approach to convert two different cellulases from the free enzyme system of Thermobifida fusca into bifunctional enzymes with different modular architectures and examined their performance compared to those of the combined parental free enzyme and equivalent designer cellulosome systems.
In addition to sexual recombination, the problem of genetic linkage for behaviorally complex organisms may be mitigated by entrusting evolution with the task of finding appropriate modular architectures and learning with the task of finding the appropriate connection weights for these architectures.
Specific approaches, such as using modular architectures and redundancy are suitable only up to a certain level of functionality.
Cellulase-cellulase multifunctional enzymes observed to date present a variety of modular architectures and include combination of two catalytic modules (GH6 with GH12, GH9 with GH48, GH5 with GH12 or GH5 with GH6) with a minimum of one CBM (from families 2, 3, 5 and 10) and could contain supplementary ancillary modules such as FN3-like modules [ 1, 12].
Despite the potential limitations related to knowledge incompleteness and uncertainty in the network inference process, the characterization of complex biological phenomena on the basis of functional modular architectures and topological parameters present us with new opportunities to improve our understanding of the evolution, operation and possible re-engineering of these systems [ 6, 13, 14].
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Important research directions include vehicle autonomy, microelectronic and microelectromechanical systems, ion engines, modular architecture and multifunctional systems, and high-efficiency solar arrays that replace silicon cells with significantly more effective photovoltaic materials such as gallium arsenide.
Claims that the mind has a modular architecture, and even massively modular architecture, are widespread in cognitive science (see e.g. Hirshfield and Gelman 1994).
The functionality model, modular architecture and data flow of the system are proposed.
Third, the modular architecture and the software implementation can be customized with modest efforts.
This strategy is generalizable to other detection algorithms with modular architecture and spectral filters.
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