Sentence examples for modifying the phenotype from inspiring English sources
It is possible that the manifestation of the most severe phenotype is due to an unlikely combination of genetic and non-genetic factors (endogenous or environmental factors, which may be precipitating or modifying the phenotype).
Indeed, any disturbance in the process of differentiation should in theory result in an increase in the sensitivity of the targets to NK cell mediated cytotoxicity since this process is important for modifying the phenotype of NK cells to cytokine secreting cells in order to support differentiation of the remaining viable competent cells.
Despite this, we consider that the small deleted region at chromosome 3p could be modifying the phenotype of our patient.
We caution, however, that genetic proof of sfl as modifying the phenotype in this population will require additional studies.
On the other hand, it has been shown that by targeting the metabolites correlated with an objective phenotype, gene targets for modifying the phenotype could be selected [ 22].
Our results revealed that IL-6 determines susceptibility to helminth infection by modifying the phenotype of the Treg-cell population and limiting protective Th2 responsiveness.
Using these stocks, we then tested the capacity of components of the Rb-E2F pathway to modifying the phenotypes.
Subsequently, any elements modifying the phenotypes were discarded if they produced a phenotype in the absence of CLN3 overexpression, even if the phenotypes were very different.
AHI1 seems to act as a modifier of CEP290[ 133] and NPHP1[ 134], and PDZD7 can modify the phenotype in Usher syndrome patients who have a homozygous USH2A mutation [ 135].
Gene transfer is a therapeutic strategy which uses genetic information, usually in the form of DNA, to modify the phenotype of cells.
These results collectively indicate that microenvironmental factors can uniquely modify the phenotype of differentiated recruited monocytes inducing marked changes in mRNA levels and also in miRNA expression and kinetics that may modulate the remarkable flexibility of monocyte responses to specific environmental cues.
