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If such a change occurs in humans during aging, this would be consistent with miRNAs modifying the onset of polyglutamine disease, which typically takes place after middle-age.
A higher prevalence of mini-kinase neurofibrillary tangles in the brains of people with Down syndrome and people with early-onset Alzheimer's disease suggest that the overexpression of the DYRK1A gene in trisomy 21 may be the factor modifying the onset and progression of neurofibrillary degeneration in Down syndrome [ 32, 53, 54].
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This work was designed to determine whether melatonin treatment at the spring equinox can induce reproductive activity in goats without separation from males (separation being the normal practice in Spanish farming systems) and whether this treatment modifies the onset of the natural breeding season.
Local emissions from vehicles in the surroundings of ski resorts not only reduce the whiteness of the snowy landscape affecting the attractiveness to visitors, but also modify the onset of snowmelt and thus the environmental equilibrium of the local area and of the surrounding region.
This chemical modified the onset pressure of asphaltene precipitation of light oil from 4300 psi to about 3600 psi and decreased the precipitated asphaltene of heavy oil by about 30%%.
The c-a transition of Ge QDs does not modify the onset of light absorption neither the spectrum itself, except that for the disappearance of the direct resonance peaks as expected because of the lost crystalline order within the Ge QDs.
For the other two measures, education did not significantly modify the onset of terminal decline.
A decade ago, ingested INF-α was reported to modify the onset of autoimmune diabetes in a commonly used animal model, the nonobese diabetic (NOD) mouse.
13 This suggests that additional genetic and/or environmental factors may modify the onset and severity of PCH in association with EIF2AK4 mutations.
Given the serious and occasionally tragic consequences of misdiagnosis of bipolar II depression as unipolar depression in the postpartum period, it is argued that DSM-V should consider modifying the postpartum-onset specifier to include episodes of hypomania.
These results suggest that N2O3 does not affect the bistable character of the response to EC stimuli, except for modifying the threshold for onset of apoptosis, which is shifted to higher [casp8]0 (i.e. rendered more difficult) with decreasing [GSH]0.
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