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Interestingly, this effect can be also obtained in our case by modifying the level of depression (note that in the present study we use a logarithmic scale for the frequency domain, which indicates that the second resonance peak is in fact a very broad peak).

Thus, the activity of MRFs can be regulated by modifying the level of the MRF or one of its partners.

Also, there is evidence that these sequences act as transcription regulatory elements where the number and type of repeat units play a crucial role in modifying the level of transcription and, therefore, gene regulation even in neighbour genes [ 49– 52].

Recently, generation of mouse models in which the level of specific ROS and/or enzymes modifying the level of ROS is altered has provided us with valuable information regarding the role of ROS in mediating aging in mammalian hearts.

Activity altering polymorphisms in FasR (−1377G > A and -670A > G), FasL (−844 T > C) and CASP8 (−652 6 N ins/del) genes have been shown to alter the mechanism of apoptosis by modifying the level of expression of their correspondent proteins.

Similar(55)

Biliary obstruction itself disadvantages the immune system and impairs its capability to fight infection, by impairing the function of certain immune system cells (neutrophil granulocytes) and modifying the levels of immune hormones (cytokines).

Very interestingly, we also observed the marked difference in modifying the levels of the reduced glutathione (GSH, an endogenous antioxidant) in normal and cancer cells.

Expression of endogenous carotenoid genes is often altered as a consequence of manipulations modifying the levels of biosynthetic intermediates in the pathway.

These proteins can be divided into two groups, with either pro- or anti-apoptotic roles; modifying the levels or activity of these proteins disrupts the cellular apoptotic balance.

This would predict that lengthy exposure to the drug will influence translation by modifying the levels of initiation and elongation factors.

Al has also been shown to impact root growth by modifying the levels of phytohormones such as auxin [ 89] and ethylene [ 8].

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