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The "field programmable" portion of the FPGA's name refers to the fact that its programming takes place "in the field", meaning that FPGAs are configured in the laboratory, or it may refer to modifying the function of a device resident in an electronic system that has already been deployed in the outside world.
A less likely possibility is that LPA might act indirectly by modifying the function of a PPARγ coactivator.
Phosphorylation by Cdks directs the cell cycle by modifying the function of regulators of key processes such as DNA replication and mitotic progression.
Unlike the dominant effect of germline p53 mutation on cancer risk, germline p53 polymorphisms exert more subtle effects on tumor onset or risk of cancer by modifying the function of p53.
However, ubiquitin also has important roles in modifying the function of individual proteins required for specific processes, e.g. ubiquitination of PCNA (proliferating cell nuclear antigen) is required for bypass of replication blocking lesions in DNA [6], [7], [8].
These moieties are also capable of reacting with thiol groups by Michael addition, thereby modifying the function of target proteins.
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Lysosomal proteases are also involved in the degradation of proteins not only to inactivate proteins but also for modifying the functions of some proteins [39].
Proteolysis is a cellular mechanism not only for maintaining the concentration of proteins but also for regulating or modifying the functions of proteins [33], [34].
17 NE is a neurotransmitter; it spills over into the systemic circulation, further modifying the functions of the liver, adrenal cortex, pancreas, and kidneys.
Multi-target approaches are necessary to properly analyze or modify the function of a biochemical pathway or a protein family.
Cleavage of OPN by PC5/6 may modify the function of OPN in bone and/or modulate other enzymatic cleavages of OPN, leading to alterations in the bone phenotype.
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