Sentence examples for modifying the efficiency of from inspiring English sources

Therefore, it is reasonable to speculate that the COX-2.8473 polymorphism, located downstream of the stop codon in the adenylate/uridylate-rich 3'-UTR region [ 20], could partly decrease mRNA stability and expression either by modifying the efficiency of polyadenylation signals or by affecting the binding affinity of regulatory elements.

Thus, polymorphisms in 3′UTR region could create, destroy or modify the efficiency of miRNA binding to the 3′UTR of a gene, resulting in gene dysregulation at posttranscriptional level.

One potential source for the latter is SNPs which create, destroy, or modify the efficiency of miRNA binding to the 3'UTR of a gene.

Recent findings indicate that SNPs could create, destroy, or modify the efficiency of miRNA binding to the 3'UTR of a gene, resulting in gene dysregulation.

We might hypothesize that deactivation of PC-PLC isoform(s) associated with HER2 likely modifies the efficiency of ubiquitinylation and lysosomal degradation through changes in steric hindrance effects or structural changes of HER2 complexes or both.

This regulation can modify the efficiency of the TLR4-signalling pathway and thus affect host innate defences against microbial pathogens [ 88]. miR-21 also inhibits the expression of MyD88 and IRAK1, leading to the upregulation of the JNK/c-Jun signalling pathway, the ERK/c-Fos pathway, and signalling by type I IFNs during RNA virus infection [ 54].

In contrast, no significant change in expression levels of Xp alleles (except from Xist, as mentioned previously) was observed in GSK126-treated compared to untreated XEN cells, indicating that the marked reduction of H3K27me3 on the Xi of XEN cells did not significantly modify the efficiency of Xi gene silencing.

Finally, sub-class 4 contains a large set of 24 factors that take into account all putative enzymes linked to the epigenetic histone code and predicted to modify the efficiency of transcription, mostly Histone Acetyl Transferases (HATs) and Histone DeACetyl transferases (HDACs) including SIR2 proteins.

Our work highlights the intricate relationship between upconversion efficiency and lattice geometry and provides a promising approach to modifying the quantum efficiency of any lanthanide upconverter.

This might alter the efficiency of the treatment by modifying the irradiation geometry.

We first examined whether aging could modify the transduction efficiency of our lentiviral vectors and/or change the efficacy of the promoter driving the expression of mutant Htt.