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Therapeutic drug monitoring (TDM) is the process of obtaining the serum concentration of a medication and modifying the dose based on the results.
Side effects of diarrhea might require modifying the dose.
There is also the possibility of further reducing de Gramont drug costs by modifying the dose.
At present, the available evidence does not support modifying the dose or frequency of nebulized antibiotics in obese patients.
The protocol was designed to delay treatment until resolution of treatment related toxicity instead of modifying the dose of treatment.
Our findings are in accordance with previous studies showing that the presence and length of treatment-free intervals are major determinants in the development of drug resistance in tumour cells, and that drug resistance acquisition can be hindered, prevented and even circumvented simply by modifying the dose and schedule of chemotherapy administration [ 1, 19, 20].
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We have assessed the drug levels after modifying the doses of isoniazid and rifampicin.
In a study by Gelman and Taylor (1984), the age-related increase in toxicity with CMF was eliminated by modifying the doses of methotrexate and cyclophosphamide based on renal function, and empirically decreasing the dose of 5FU by two-thirds.
Furthermore, by modifying the doses of XP to manage adverse reactions, XP could be one of the standard regimens for the first-line treatment of unresectable advanced or recurrent gastric cancer in Japan.
In the other case, the FDA allowed the trial to resume after investigators modified the dose that would be used.
Dosing was flexible, such that PIs could prescribe from one to four capsules per day, and could modify the dose based on a patient's symptoms and side effects.
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