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Our results suggest that the mitochondrial DNA background plays an important role in modifying the disease phenotype but nuclear modifiers, epigenetic and environmental factors may also influence the severity of disease.
Imaging of tau lesions in living tauopathy patients has been enabled recently, and in vivo quantification of tau pathologies would improve accuracy of diagnosing these disorders and facilitate objective assessments of anti-tau treatments capable of modifying the disease process.
For this purpose, chemical agents are screened for their ability to interact with the target, and agents that can interact with the target have the potential of modifying the disease process.
In contrast, other B. burgdorferi antigens are also described, such as BmpA/B [13] and Arp [50], [51], that fail to protect host against B. burgdorferi infection, but influence pathogenesis either by reduction of the B. burgdorferi burden in selected tissues [13] or by modifying the disease without affecting spirochete load [50], [51].
Current pharmacological treatment of RA focuses on alleviating symptoms and/or modifying the disease process.
In addition, the idea of modifying the disease environment surrounding mDA neurons is appearing on the therapeutic horizon.
Similar(44)
"The drugs available at the moment can hold cognitive function, but they don't modify the disease," says neurologist Professor Giovanna Mallucci, programme leader at the Medical Research Council's toxicology unit.
A mechanistic approach to the discovery of key pathogenic brain modifications causing seizure onset, recurrence and progression is instrumental for designing novel and rationale therapeutic interventions that could modify the disease course or prevent its development.
These 21-bp repeats confer a replicative advantage to the virus rather than modify the disease spectrum [44], [47]; they were not investigated in the present study.
In addition, it has been shown that exposure to an enriched environment was able to modify the disease course in mouse models of RTT.
It is worth investigating whether administration of α-methyldopa at this point might have an effect on levels of anti-angiogenic factors and modify the disease process.
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