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Computational studies have been carried out to uncover active sites and interaction of PSMA inhibitors with the protein by modifying the core structure of the ligand.
Lysine acetylation was first discovered in histone proteins (Allfrey et al. 1964; Phillips 1963) and its role has been extensively investigated in regulating gene transcription by histone acetyltransferases (HATs) or histone deacetylases (HDACs) modifying the core histone tails (Lee and Workman 2007; Yang and Seto 2008).
The present study does not resolve the issue of whether the stabilized forms of Mad interact directly at the protein-protein binding level, thus modifying the core Wg pathway, or at level of DNA enhancers.
We successfully controlled the critical micelle concentration and micelle size of polyester based systems solely by modifying the core crystallinity, thereby establishing this as a strategy for tailoring of the CMC and micelle size.
An interdisciplinary team took stock of all the information-gathering activities within the Ministry with a view to identifying the needs for modifying the core and complementary information systems for workforce planning and management.
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Moving those configurations, you can modify the core, and then you can get the new modified core.
Simple experiments can be performed with little knowledge, while experts can still access and modify the core functionality.
Further, a simple and elegant mechanism exists for customization of code functionality without the need to modify the core implementation of the source.
Unlike previous attempts, we do not modify the core compiler or type-checker, and instead use the camlp4 metaprogramming tool to generate appropriate definitions at compilation time.
User-developed additions to sigTOOL that are archived and distributed electronically will be added to the sigTOOL interface on-the-fly, without the need to modify the core sigTOOL code.
The program can handle simulations of the diffusion and reaction of millions of particles in one, two, or three dimensions, and is designed to be easily extended and customized by the user to allow for the development of complex custom KMC models for specific systems without having to modify the core functionality of the program.
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