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For the discrete risk model, Tan and Yang [16] propose a randomized dividend strategy by modifying the compound binomial model.
The environmental interventions in this study focus on modifying the compound environment to reduce infant exposure to enteric pathogens.
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Some brewers get around that problem by extracting the bitter compounds from hops, a process analogous to producing vanilla extract from vanilla, and modifying the compounds so that they are no longer susceptible to light.
Then, they may give the effective ones to animals and evaluate the outcomes, modifying the compounds by changing the chemical structure and retesting them, in successive rounds, to make them perform better, with fewer untoward side effects.
Screening or modifying the compounds targeting the mevalonate pathway would be one direction to inhibit the oncogenic roles of TAZ in human cancer.
In addition, the collected dataset allowed the development of bioisosteric matrices qualitative and quantitative descriptions of the biological effects of each predefined type of bioisosteric substitution, providing favored paths of modifying the compounds.
Once a chemical was found to restore the movement of chloride, the team worked to modify the compound into potable forms that might serve as drugs.
Gerber et al. [7] modify the compound binomial risk model by dividend payments.
Biotransformation offers chemo enzymatic system to modify the compounds into their novel analogues which are difficult to synthesize by chemical methods.
The selection was based on diversity of chemical structure and opportunities to further modify the compounds.
Oxidative stress, generated by the oxygen-rich environment and the exposure to light in the eye, modifies the compounds in the photoreceptors, which are then shed in the form of photoreceptor outer segments (POS) and phagocyted by RPE cells (Beatty et al. 2000).
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