Sentence examples for modifying the chromatin from inspiring English sources

Recent genetic and biochemical studies have elucidated the mechanisms of NuRD action in modifying the chromatin landscape.

Histone modifications and DNA methylation play a critical role in regulating gene expression by modifying the chromatin structure of genes and recruiting additional regulatory factors.

Collectively, these data suggest that MLL can activate genes at inappropriate times by mis-targeting histone mark 'writers', consequently modifying the chromatin to allow gene activation.

HDACs modulate transcriptional activity of hormonal receptors including AR, for example, by altering the stability of the transcriptional pre-initiation complex and/or modifying the chromatin structure.

Collectively, these data are consistent with the view that Yki activates target gene transcription by interacting with the Trr methyltransferase complex and modifying the chromatin state of the target loci.

PcG proteins exist in distinct multi-protein complexes that repress transcription by modifying the chromatin of target genes and thereby generating transcriptional off states that can be stably and heritably maintained (Francis and Kingston, 2001; Schwartz and Pirrotta, 2007).

These complexes have been demonstrated to modify the chromatin structure that is associated with transcriptional activation.

PcG proteins are recruited to specific regulatory elements to modify the chromatin surrounding them.

These roles may be partially mediated by Myc's capacity to modify the chromatin landscape on a global scale.

Epigenetic alterations of chromatin such as histone acetylation do not alter the DNA sequence but modify the chromatin architecture and its accessibility, resulting in repressed gene transcription.

Epigenetic regulation, which modifies the chromatin architecture to facilitate gene expression at specific loci of the genome, is a rapidly developing field of research.