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We focus specifically on the ability of genes to change their expression by modifying the accessibility of RBS, or in other words, 'RBS exposure'.
In one type of post-transcriptional regulation, which is usually governed by the RNA chaperone Hfq in Gram-negative bacteria, sRNAs interact with specific mRNA targets, thereby modifying the accessibility of the Shine-Dalgarno sequence to the translational machinery and often altering the stability of the mRNA.
Thus, glucose may regulate SNF1 activity by modifying the accessibility of the complex to the Reg1/ Glc7 phosphatase, perhaps through reduction in ADP levels or through modulation of the interaction between SNF1 and Reg1 (Dombek et al. 2004; Rubenstein et al. 2008; von Plehwe et al. 2009; Mayer et al. 2011).
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The first change, I171 to V177, was located far from the entrance to the heme access channel, while the other three changes are located close to or at the heme access channel and modify the accessibility to the cofactor.
As a consequence, a variation in the biosorbent particle size modifies the accessibility and the availability of reactive groups present on its surface [13].
Thus, we are not at liberty to modify the accessibility relation, should we wish to do so, unless we simultaneously revise the truth conditions associated with the DRS language.
Theses complexes modify the accessibility of DNA regulatory sites through both repositioning (sliding) and ejecting nucleosomes.
These changes may not affect CpGs that directly regulate the gene expression, but they may modify the accessibility of the promoter region to transcriptional regulation or affect genome stability.
NUP153 is known to affect the sub cellular distribution of transcription factor such as SMAD2, STAT1, and PU.1 [ 35], hence, altered NUP153 expression may modify the accessibility of key regulatory proteins.
However, p16 knockdown can de-silence some E2F-targets if SAHFs are dissolved by depletion of HMGA1, suggesting that HMGA1 may contribute to the silencing of these genes, at least in part, by regulating higher-order chromatin structure to modify the accessibility of transcriptional regulators.
Su, Y. et al. Neuronal activity modifies the chromatin accessibility landscape in the adult brain.
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