For example, variation in the gene encoding T2R38 modifies sensitivity to PTC, which correlates with sensitivity to bitter compounds in cabbage or Brussels sprouts4.
Next, we tried to search for genes that modify sensitivity to another target-predicted compound, aurilide B. Its close analogue, aurilide, binds to prohibitin 1 to induce mitochondria-mediated apoptosis11.
Because aspirin and NS-398 ableable to inhibit cell growth, we asked whether they might modify sensitivity to anticancer drugs.
Loss of this protein may result in the inability of cells to repair damaged DNA and modify sensitivity to chemotherapeutic agents.
Polymorphism at this codon has been suggested to modulate TP53-dependent apoptosis and modify sensitivity to chemotherapeutic agents [ 9, 11, 12, 17].
Genetic analyses in yeast have identified many TORC1 pathway members since mutations in genes coding for these factors typically modify sensitivity to rapamycin [ 5, 8].
To delineate the mechanism by which low-dose ATO modifies sensitivity to TRAIL, activation of pro-caspase-8 in Jurkat and K562 cells was examined by following pro-caspase-8 cleavage with Western blotting and by a fluorescent IETDase assay.
LPS significantly modified sensitivity to PE at D5. Indeed, PE EC50 of rings with endothelium (E+) and rings without endothelium (E-) were similar, suggesting endothelial dysfunction, when they were significantly different in the CTRL group.
To evaluate whether uPA knockdown modifies sensitivity to TRAIL-induced cell death, uPA-depleted cells were exposed either to high doses of TRAIL during different time points or to increasing doses of the cytokine, and the percentage of apoptotic cells was analyzed.
We therefore sought to identify factors that modify sensitivity of melanoma cells to the combination treatment of Mcl-1 DsiRNA and ABT-737.
