Family-specific insertions elsewhere in the motor domain are likely to have other modifying roles, such as Kin3's loop12, which enhances the initial interaction between these highly processive motors and their tracks (Soppina and Verhey, 2014).
In a similar sense, our diet score broadly captures several dietary characteristics; therefore, neither the clinical trials data nor those from our analyses allow us to speculate on the effect modifying roles of individual dietary components.
Although GERD is multifactorial in etiology with potentially important modifying roles played by mucosal defensive factors and differences in reflux constituents, the key abnormalities in the pathogenesis of GERD are reflux of acid and pepsin from the stomach into the esophagus and a reduction in the effectiveness of esophageal acid clearance.
Other studies suggested phenotypic modifying roles for TSC2 and DKK3 [ 21, 22].
Several reports have indicated the down-regulation of LPH activity in mammals at the transcriptional level, however, subsequent post-transcriptional mechanisms may also play modifying roles [ 28– 30].
Of more interest was the potential identification of specific genes with overlapping modifying roles in different disease models and model organisms.
However unlike Ago2, which is required for siRNA mediated silencing, dFMR1 has been shown to have little to no effect on siRNA efficiency, and is therefore thought to play a stabilizing or modifying role in siRISC function [29], [30], [31].
More recently, constitutive expression of both CB1 and CB2 receptors have been isolated on chondrocytes and implicated in a potential disease modifying role in OA [ 37].
The basic premise behind PSR is that changes in a protein's subcellular location can cause it to take on new or modified roles within the cell.
See Add new users and modify roles for information about roles.
