Sentence examples for modifying proteins to from inspiring English sources
Researchers have therefore devised a range of concepts for creating or modifying proteins to catalyse reactions unknown in nature2,3,4.
After binding to DNA, HMGA1 proteins recruit additional transcription factors and histone modifying proteins to alter chromatin structure and form a higher order transcriptional complex or enhanceosome [ 16].
The TFs form complex regulatory networks at the transcriptional level and through protein protein interactions among themselves or with proteins of other classes such as RING E3 ligases for degradation or chromatin modifying proteins to recruit or block access of RNA polymerases to the DNA template.
Methylglyoxal modifies proteins to form advanced glycation end product (AGE) residues.
K48-linked polyubiquitination is well recognized as a targeting signal that allows modified proteins to undergo 26S proteasome-dependent degradation.
As demonstrated by current protocols, their unique mechanisms can be coupled with synthetic inhibitors or genetically modified proteins to create effective first-line therapies.
The scheme indicates also some more hypothetical links to observations in mammalian cells, for instance as to the post-prenylation reactions and the transport of covalently modified proteins to their intracellular destination.
Recent advances that enable large sets of modified proteins to be identified, combined with global analyses of gene expression, have provided an opportunity for a systems-based approach to study electrophile stress at the cellular level.
MGO was shown to modify proteins and to contribute to the accumulation of damaged proteins that can be toxic to cells.
Thiol reactive agents such as N-substituted maleimides and iodoacetamide can be used to modify proteins at cysteines at specific sites (17– 20).
In addition to modifying proteins, the Golgi also manufactures macromolecules itself.
