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In addition, mouse and human ARD1s have been reported to participate in post-translational protein modification via ε-amino lysine acetylation, which is a common means of modifying proteins in eukaryotes.
Alternatively, O3 may also have a direct effect on the process of allergic sensitization by modifying proteins in antigen-presenting cells that function within airways.
Engineering and modifying proteins in vivo or in vitro can aid the understanding of the biological function and structure-function relationship of proteins.
Modifying proteins in mammalian cells co- and post-translationally is of great importance both for in vivo as well as for in vitro studies of proteins in cellular mechanisms.
Recent data concerning the "chromatin ambient" of the nucleus indicate a highly qualified role for chromatin modifying proteins in the control of DNA replication and DNA-repair [ 27, 44, 45].
Amongst the group of cell wall modifying proteins in adaxial Iberis petals are several pectinases, enzymes that function in the de-/methylesterification or degradation of pectin [ 39] and, by that, might contribute to cell growth via precisely tuning the proportion of pectate in the cell wall [ 62].
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The thermo-responsive mTG is suitable to modify proteins in food processing and biomedical engineering.
Furthermore, if the enzymes can tolerate substrate analogs, it becomes possible to engineer chemically modified proteins in a site-specific fashion.
The present work significantly enlarges the number of N-terminally modified proteins in bacteria and confirms that these modifications are a general and fundamental process, not only restricted to eukaryotes.
Enolase1 is one of the most consistently up-regulated and oxidatively modified proteins in brain of subjects of early-onset AD [34].
Thirdly, SFAs especially palmitic acid, as well as their metabolic intermediate acetyl-CoA, can be directly used as substrates to modify proteins, in the forms of palmitoylation and acylation.
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