However, treadmills slightly but significantly modify gait biomechanical parameters thus confound the effects of BWU.
Herein, we explore whether SFX-01®, a stable synthetic form of sulforaphane, modifies gait, bone architecture and slows/reverses articular cartilage destruction in a spontaneous OA model in STR/Ort mice.
Our system provides a simplified vibrotactile cuing to modify gait.
SpCV mode provides information on the swing phase to modify gait parameters.
They were able to use the cue and significantly modify gait without extensive training.
Healthy joint aging is known to involve tendon stiffening (34), which may modify gait by restricting joint movement and full heel toe strike.
18 In 2008, Yogev-Seligmann et al 19 proposed a theoretical framework showing how changes in different aspects of executive function (volition, self-awareness, planning, inhibition of dominant response and external distraction during response control, dual-task coordination) can modify gait patterns.
1, 2 Verghese et al 2 showed that, depending on modified gait parameters, one can even characterize the profile of cognitive impairment (modification of velocity and length of step are factors associated with decline in executive function, whereas the frequency factor determines mnesic deterioration).
Since meniscal tears are associated with structural changes of OA (including cartilage defect scores, reduced tibial cartilage volume, and increased tibial bone area [ 2- 7, 24]), it is possible that modifying the gait parameters examined in this study (for example, via gait retraining or orthoses) may also help to reduce the incidence and burden of knee OA.
