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Histone modifying enzymes play a role in the regulation of transcription by modulating the state of chromatin, and they also cross-talk with each other (Portela and Esteller, 2010).
Thus, pectin modifying enzymes play a major role in the fibre cell wall development [ 56].
It is increasingly evident that histone modifying enzymes play a key role in hypoxia-related tumourigenesis.
It is known that ECM/cell wall modifying enzymes play important role against invading pathogens.
Chromatin modifying enzymes play a critical role in cardiac differentiation.
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It has been suggested that limiting three-dimensional diffusion of chromatin-modifying enzymes plays an important role in assembling specific chromatin domains, in particular at peri-centromeric heterochromatin 31.
In addition, gene encoding pectin modifying enzymes pectin esterases which might play a major role in the fiber cell wall development were also identified (Additional file 2; Fig. 7) in our current study.
They concluded that Cys2His2 and ADR6 transcription activators, cell wall modifying enzymes, and phytosulfokine growth factors might play roles in soybean Al tolerance [ 23].
Having indicated the necessity to have both the DNA and histone modifications correctly aligned such that the expression of a gene occurs, we point to the plethora of modifying enzymes that can have roles to play.
USF1/2 has been shown to play a critical role in mediating barrier activity of the chicken β globin gene, recruiting histone modifying enzymes [31], [32].
Restriction and modifying enzymes were purchased from MBI Fermentas.
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