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We conducted a systematic review to find evidence for our hypothesis that statin treatment has a disease modifying effect in patients with COPD and improves a) morbidity and b) mortality.
It showed that 3 years of treatment with ASU-E did not reduce the average JS loss but reduced the percentage of JSW deteriorating patients compared with placebo, possibly indicating a potential structure modifying effect in hip OA.
Moreover, in this trial, a statistically significant decrease in matrix metalloproteinase enzyme serum level suggests that, in addition to the observed symptomatic effect, such a compound might have a disease modifying effect in osteoarthritis.
3 year treatment with ASU-E reduces the percentage of JSW progressors, indicating a potential structure modifying effect in hip OA to be confirmed, and the clinical relevance requires further assessment.
Additional studies have suggested that MEFV rare missense causative mutations have a potential modifying effect in IBD patients [27] [30].
Cigarette smoking has a modifying effect in the development of oral leukoplakia.
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The best compound identified, SMT C1100, demonstrated significant disease modifying effects in DMD models.
Current oncological therapies have modest disease modifying effects in cases of non-small cell lung cancer (NSCLC), even though some disease subgroups responsive to targeted therapy have been identified in recent years.
Nevertheless, it was one of the only tests of sensory function, and the improvements in treated patients raise the possibility that VM202 has a disease modifying effect separate from effects in reducing symptoms.
However, there was a tendency towards a modifying effect of ancestry in the circumcision prostate cancer relationship.
Results of this study, although exploratory, do suggest that spatial scales play a role in modifying effect sizes of climate change response in plants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com