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These associations point toward select chromatin modifying complexes and enzymes as likely epigenetic drivers of EMT.
This requires binding to specific E-boxes throughout the genome, followed by recruitment of chromatin modifying complexes and transcription machinery.
Despite some of the great advances in our understanding of chromatin modifying complexes and their determinants, the development of ChIP-Seq technologies also pose specific demands on the integration of data for visualization, manipulation and analysis.
Similarly, several large lncRNAs transcribed antisense of protein-coding genes and they can also interact with chromatin modifying complexes and affect the landscape of chromatin [ 181, 182].
SATB1 has also been shown to interact with chromatin modifying complexes and to regulate histone modification and nucleosomal positioning over large regions (Yasui et al, 2002).
ZF-CxxC domain-containing proteins are found in chromatin modifying complexes and therefore play an unexpected and proactive role in specifying unique chromatin modification architecture at CGI associated gene promoters.
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We validated a number of these in the laboratory, including new interactions linking the SWR-C chromatin modifying complex and the nuclear transport apparatus.
These proteins act as histone chaperones and associate with additional chromatin modifying complexes including SIN3A, PRC2 and NURF [ 40– 40].
They also actively regulate chromatin remodeling via histone modifying complexes, such as MYS3 and SET [19].
ARP6 is commonly found in various kinds of chromatin remodeling and modifying complexes [ 22], regulating sets of gene activation or silencing.
Mis16 is the S. pombe homologue of RbAp46/48, a general histone H3/H4 chaperone that forms part of several chromatin assembly, remodelling and modifying complexes.
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