Also, release of MDC1 from chromatin could change chromatin conformation in a way specific for high NaCl.
Others act by modifying chromatin structure.
SUMO is capable of binding to chromatin by modifying chromatin remodeling proteins and transcription factors [ 48].
Cho, H. et al. A human RNA polymerase II complex containing factors that modify chromatin structure.
Moreover, these sequences act cooperatively in reporter gene constructs and recruit proteins that modify chromatin structure.
In keeping with this knowledge, it is important to note that hybridization and other stresses that lead to genome instability are also events that modify chromatin formatting.
These drugs, called epigenetic inhibitors, function to modify chromatin structure.
HMGN1 protein binds to nucleosome and modifies chromatin structure.
Specifically, RA binding to RARα triggers both the dissociation of corepressors proteins, and the recruitment of coactivators and histone modifying enzymes that enable chromatin conformation changes compatible with the access and action of RNA polymerase II [4], [5].
We then postulated that global manipulations of the histone code using chromatin modifying agents could change the cell-specific chromatin conformation of fibroblasts and render it more prone to activation by transfected oligodendrocyte-specific TFs.
