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It has been postulated that the coating with Xist modified chromatin configuration creates a territory containing repetitive sequences into which genes can be recruited to be silenced (Chaumeil et al. 2006; Clemson et al. 2006).
Others act by modifying chromatin structure.
SUMO is capable of binding to chromatin by modifying chromatin remodeling proteins and transcription factors [ 48].
Cho, H. et al. A human RNA polymerase II complex containing factors that modify chromatin structure.
The Kingston lab is interested in understanding the fundamental mechanisms of how eukaryotic enzymes can modify chromatin.
It is possible that interaction with histone H2A modifies chromatin to regulate downstream gene expression.
Conversely, the molecular interplay between chromatin effector proteins and modified chromatin regions as well as their resulting biological output is less well understood on a molecular level.
Moreover, these sequences act cooperatively in reporter gene constructs and recruit proteins that modify chromatin structure.
In keeping with this knowledge, it is important to note that hybridization and other stresses that lead to genome instability are also events that modify chromatin formatting.
These drugs, called epigenetic inhibitors, function to modify chromatin structure.
HMGN1 protein binds to nucleosome and modifies chromatin structure.
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