Another benefit of this MEA AD model, compared to our patch-clamp experiments, was that we were able to follow the time course of the action of curcumin on the Aβ modified activity of the same population of cells.
A wide range of modifying activities acts on nucleosome, a central unit of chromatin, including histone chaperones, ATP-dependent chromatin remodeling factors (remodelers), and histone modifying enzymes.
To the best of our knowledge, this is the first report on resistance modifying activity of TQ against resistant oral bacteria.
PC exerts its disease-modifying activity on OA, at least in part, by suppressing immune system activation and stimulating the production of extracellular cellular matrix proteins and chondroprotective proteins.
PC exerts its disease-modifying activity on OA, at least in part, by targeting abnormal immune system activation in OA.
PC exerts its disease-modifying activity on OA through two independent actions, a crystal-dependent action and a crystal-independent action.
These findings together suggest that PC exerts its disease-modifying activity on OA, at least in part, by targeting abnormal inflammatory response and angiogenesis in OA.
The specific upregulatory activity of PC on THBS1 (1.68-fold change) and FGF9 (a preferred ligand for FGFR3) indicates that PC may exert its disease-modifying activity on OA in part by modulating the FGF signaling pathway.
In this study, we sought to examine the biological activities of PC in the absence of calcium crystals and test the hypothesis that PC has unique crystal-independent biological activities which may be responsible, at least in part, for its disease-modifying activity on OA and that PC is potentially a meniscal protective agent.
