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Therefore, it is conceivable that a larger number of introns enables functionally important genes to use alternative splicing to adjust and modify their functions on the basis of developmental stage or tissue type.
To this end, strategies to deplete monocytes/macrophages or modify their functions could be applied in these models.
Tetraspanins are transmembrane proteins that serve as scaffolds for multiprotein complexes containing, for example, integrins, growth factor receptors and matrix metalloproteases, and modify their functions in cell adhesion, migration and transmembrane signaling.
Several other studies also have explored how duplicated genes maintain, lose, or modify their functions (Jukes and Cantor1969; Gibson and Goldberg 2008; Innan and Kondrashov 2010; Li et al. 2012).
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It has been reported recently that reporter fusion to connexins can modify their function.
Receptor activity-modifying proteins (RAMPs) provide a notable example of proteins that interact with GPCRs to modify their function.
Metabolic engineering is the field of introducing genetic changes in organisms so as to modify their function towards synthesizing new products of high impact to society.
Recent work has shown that Cys-loop receptors are present on immune cells, but their physiological roles and the effects of drugs that modify their function in the innate immune system are currently unclear [2].
An alternative to blocking or silencing laminin-binding integrins would be to modify their function.
Our split-GAL4 drivers give us the capability to express genetically encoded effectors in identified MBONs to modify their function.
The transduction of intracellular Ca2+ signals into physiological responses is mediated by Ca2+ sensor proteins that interact with specific target proteins to modify their function [ 1].
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