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Several of the reported factors could modify the toxicity of chemicals [29].
The latter two genes were recently reported to modify the toxicity of α-syn [33].
Genetic screens [21], [24], [25] have identified many genes that modify the toxicity of α-syn, but one of the most intriguing findings is that genes involved in lipid metabolism and vesicle trafficking preferentially modify the toxicity of α-syn [24].
Nutritional status can substantially modify the toxicity of environmental pollutants.
Hsp104WT did not modify the toxicity of any of the TDP-43 variants (Fig. 1B).
We next examined whether overexpressing Crym could modify the toxicity of an N-terminal fragment of mHtt.
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We demonstrated that the use of an air cabin inlet filter, especially when combined with an active charcoal component, was highly effective to reduce exposure to PM, NOx and hydrocarbons from engine exhaust; with evidence that the combination filter also modified the toxicity of the filtered particles making them less pro-inflammatory in-vitro after filtration.
The CALM/PICALM gene has also been directly implicated in alterations in cognitive function with increasing age (Mengel-From et al., 2011) in risk of developing Alzheimer's disease (Harold et al., 2009) and in modifying the toxicity of Aβ in a yeast, C. elegans and primary rat cortical neuron models (Treusch et al., 2011).
Genetic factors may influence the availability of sulfhydryl-containing compounds such as glutathione and metallothionein, which modify the distribution and toxicity of certain metals.
Our results show that water quality could modify the fate and toxicity of encapsulated λ-cyhalothrin in aquatic environments, suggesting understanding their aquatic interactions are critical in environmental risk assessment.
We found that modification of both GNRs and sGNPs with linear PEI resulted in more active uptake by cells in comparison with GNRs and sGNPs modified with BSA, although both BSA and PEI coatings reduced the toxicity of modified GNPs.
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