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Therefore, significant efforts have been made in recent years to not only identify disease-causing genes but also genes that modify the severity of NDs, so-called genetic modifiers.
A considerable component of the variability in heart failure outcome is due to modifier genes, i.e. genes that are not involve in the genesis of a disease but modify the severity of the phenotypic expression once the disease has developed.
The broad variability in heart failure patient outcome is in part secondary to modifier genes, i.e. genes that are not involved in the genesis of a disease but modify the severity of the phenotypic expression once the disease has developed.
Previous studies have suggested that mineral content of the diet may modify the severity of the clinical phenotype in PXE.
Genetic studies examining seemingly healthy people have revealed, for example, rare mutations in chemokine (C-C motif) receptor type 5 (the co-receptor for human immunodeficiency virus) that block HIV infection (8), and secondary mutations in fetal globin genes that modify the severity of sickle cell disease by buffering primary mutations in β-globin genes (9).
Vaccination four to seven days after exposure can offer some protection from disease or may modify the severity of disease.
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Still, the earlier infection did not protect against West Nile infection, though it may have modified the severity of the worker's illness.
We examined whether statin use also modifies the severity of symptomatic gallstone disease and its treatment.
Anxiety is relatively common in depression and capable of modifying the severity and course of depression.
SMN2, which is highly homologous to SMN1, modifies the severity of disease.
27 Whether earlier treatment with an antiviral agent could have modified the severity of illness is unknown.
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