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Genome editing with the CRISPR/Cas9 system is making it possible to modify the sequence of genes linked to these disorders.
You can modify the sequence that you incorporate into your siRNA, and then you can target it to whatever gene you want to shut down or control the expression of," Morton says.
Here we demonstrate that a trans-splicing group I ribozyme can be employed to intentionally modify the sequence of targeted transcripts in tissue culture cells.
Several studies have been carried out to modify the sequence of GLP-1 in order to prevent degradation while conserving its valuable function.
The program does not modify the sequence of the images, except to invert the sequence if the first energies are in a decreasing order.
Moreover, RNA editing can modify the sequence of miRNAs and the nCounter system would have not detected such editing events.
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With ITS2-specific modifications, it was also necessary to modify the sequencing primers that are added to the MiSeq flow cell.
We modified the sequence the amino acid sequence of this peptide (KNYSSSISSIHAC), by replacing and deleting amino acids to obtain higher LPS-binding affinity and greater resistance to protease digestion.
Since then, many authors have conducted research on modifying the sequence in (6) so that the strong convergence is guaranteed, cf. [10 19] and the references therein.
After turning off the reverse-complement search and modifying the sequence file parsing routine, Strand was able to train and classify against malware data with no other changes.
This model could be tested experimentally in vivo by modifying the sequence lengths of reporters and studying the effects on chromosome structure using chromosome-structure capturing assays [24].
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